IMPROVEMENT IN DIASTOLIC INDICES BY RANOLAZINE: A POTENTIAL MECHANISM FOR ITS ANTI-ISCHEMIC AND ANTIARRHYTHMIC EFFECTS
نویسندگان
چکیده
منابع مشابه
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Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina.
OBJECTIVES The primary objective of the Monotherapy Assessment of Ranolazine In Stable Angina (MARISA) trial was to determine the dose-response relationship of ranolazine, a potentially new anti-anginal compound, on symptom-limited exercise duration. BACKGROUND Fatty acids rise precipitously in response to stress, including acute myocardial ischemia. Ranolazine is believed to partially inhibi...
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Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome.
Prolongation of the QT interval of the ECG is associated with increased risk of torsades de pointes ventricular tachycardia. Ranolazine, a novel antianginal agent, is reported to decrease the delayed rectifier potassium current, I(Kr), and to increase action potential duration (APD) and the QT interval. However, ranolazine is also reported to reduce late sodium current (late I(Na)), a depolariz...
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BACKGROUND Amiodarone and ranolazine have been characterized as inactivated- and activated-state blockers of cardiac sodium channel current (I(Na)), respectively, and shown to cause atrial-selective depression of I(Na)-related parameters. This study tests the hypothesis that their combined actions synergistically depress I(Na)-dependent parameters in atria but not ventricles. METHODS AND RESU...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2015
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(15)60385-0